Clarithromycin attenuates IL-13–induced periostin production in human lung fibroblasts

Clarithromycin attenuates IL-13–induced periostin production in human lung fibroblasts

Abstract Background Periostin is a biomarker indicating the presence of type 2 inflammation and submucosal fibrosis; serum periostin levels have been associated with asthma severity. Macrolides have immunomodulatory effects and are considered a potential therapy for patients with severe asthma. Ther...

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Bibliographic Details
Main Authors: Kosaku Komiya, Shoichiro Ohta, Kazuhiko Arima, Masahiro Ogawa, Shoichi Suzuki, Yasutaka Mitamura, Satoshi Nunomura, Yasuhiro Nanri, Tomohito Yoshihara, Atsushi Kawaguchi, Jun-ichi Kadota, Bruce K. Rubin, Kenji Izuhara
Format: Article
Language:English
Published: BMC 2017-02-01
Series:Respiratory Research
Subjects:
Macrolide
Periostin
Asthma
Fibroblast
IL-13
Online Access:http://link.springer.com/article/10.1186/s12931-017-0519-8

Internet

http://link.springer.com/article/10.1186/s12931-017-0519-8

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