Mck1 defines a key S-phase checkpoint effector in response to various degrees of replication threats.

Mck1 defines a key S-phase checkpoint effector in response to various degrees of replication threats.

The S-phase checkpoint plays an essential role in regulation of the ribonucleotide reductase (RNR) activity to maintain the dNTP pools. How eukaryotic cells respond appropriately to different levels of replication threats remains elusive. Here, we have identified that a conserved GSK-3 kinase Mck1 c...

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Bibliographic Details
Main Authors: Xiaoli Li, Xuejiao Jin, Sushma Sharma, Xiaojing Liu, Jiaxin Zhang, Yanling Niu, Jiani Li, Zhen Li, Jingjing Zhang, Qinhong Cao, Wenya Hou, Li-Lin Du, Beidong Liu, Huiqiang Lou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-08-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008136

Internet

https://doi.org/10.1371/journal.pgen.1008136

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