Next Generation Sequencing Assay for Detection of Circulating HPV DNA (cHPV-DNA) in Patients Undergoing Radical (Chemo)Radiotherapy in Anal Squamous Cell Carcinoma (ASCC)

Next Generation Sequencing Assay for Detection of Circulating HPV DNA (cHPV-DNA) in Patients Undergoing Radical (Chemo)Radiotherapy in Anal Squamous Cell Carcinoma (ASCC)

Background: Following chemo-radiotherapy (CRT) for human papilloma virus positive (HPV+) anal squamous cell carcinoma (ASCC), detection of residual/recurrent disease is challenging. Patients frequently undergo unnecessary repeated biopsies for abnormal MRI/clinical findings. In a pilot study we asse...

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Bibliographic Details
Main Authors: Jen Y. Lee, Rosalind J. Cutts, Ingrid White, Yolanda Augustin, Isaac Garcia-Murillas, Kerry Fenwick, Nik Matthews, Nicholas C. Turner, Kevin Harrington, Duncan C. Gilbert, Shreerang Bhide
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Oncology
Subjects:
Plasma HPV-DNA
chemo-radiation
anal cancer
locally advanced
response prediction
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00505/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00505/full

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