Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

Human NimA-related kinases (Neks) have multiple mitotic and non-mitotic functions, but few substrates are known. We systematically determined the phosphorylation-site motifs for the entire Nek kinase family, except for Nek11. While all Nek kinases strongly select for hydrophobic residues in the −3 p...

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Bibliographic Details
Main Authors: Bert van de Kooij, Pau Creixell, Anne van Vlimmeren, Brian A Joughin, Chad J Miller, Nasir Haider, Craig D Simpson, Rune Linding, Vuk Stambolic, Benjamin E Turk, Michael B Yaffe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
mitosis
kinase biology
Nima-related kinase
Nek kinase family
substrate specificity
signaling
Online Access:https://elifesciences.org/articles/44635

Internet

https://elifesciences.org/articles/44635

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