Fucoidan Ameliorates Renal Injury-Related Calcium-Phosphorus Metabolic Disorder and Bone Abnormality in the CKD–MBD Model Rats by Targeting FGF23-Klotho Signaling Axis

Fucoidan Ameliorates Renal Injury-Related Calcium-Phosphorus Metabolic Disorder and Bone Abnormality in the CKD–MBD Model Rats by Targeting FGF23-Klotho Signaling Axis

Background: Recently, chronic kidney disease (CKD)-mineral and bone disorder (MBD) has become one of common complications occurring in CKD patients. Therefore, development of a new treatment for CKD–MBD is very important in the clinic. In China, Fucoidan (FPS), a natural compound of Laminaria japoni...

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Bibliographic Details
Main Authors: Bu-Hui Liu, Fee-Lan Chong, Can-Can Yuan, Ying-Lu Liu, Hai-Ming Yang, Wen-Wen Wang, Qi-Jun Fang, Wei Wu, Mei-Zi Wang, Yue Tu, Zi-Yue Wan, Yi-Gang Wan, Guo-Wen Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
fucoidan
chronic kidney disease-mineral and bone disorder
FGF23-Klotho signaling axis
phosphorus reabsorption
ERK1/2-SGK1-NHERF-1-NaPi-2a pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.586725/full

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https://www.frontiersin.org/articles/10.3389/fphar.2020.586725/full

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