TM4SF1 promotes EMT and cancer stemness via the Wnt/β-catenin/SOX2 pathway in colorectal cancer

TM4SF1 promotes EMT and cancer stemness via the Wnt/β-catenin/SOX2 pathway in colorectal cancer

Abstract Background Transmembrane 4 L six family member 1 (TM4SF1) is upregulated in several epithelial cancers and is closely associated with poor prognosis. However, the role of TM4SF1 and its potential mechanism in colorectal cancer (CRC) remain elusive. Methods We investigated the expression of...

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Bibliographic Details
Main Authors: Qiang Tang, Jinhuang Chen, Ziyang Di, Wenzheng Yuan, Zili Zhou, Zhengyi Liu, Shengbo Han, Yanwei Liu, Guoguang Ying, Xiaogang Shu, Maojun Di
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
TM4SF1
Colorectal cancer
SOX2
Stemness
EMT
Wnt/β-catenin
Online Access:http://link.springer.com/article/10.1186/s13046-020-01690-z

Internet

http://link.springer.com/article/10.1186/s13046-020-01690-z

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