Down-regulation of complement receptors on the surface of host monocyte even as in vitro complement pathway blocking interferes in dengue infection.

Down-regulation of complement receptors on the surface of host monocyte even as in vitro complement pathway blocking interferes in dengue infection.

In dengue virus (DENV) infection, complement system (CS) activation appears to have protective and pathogenic effects. In severe dengue fever (DF), the levels of DENV non-structural-1 protein and of the products of complement activation, including C3a, C5a and SC5b-9, are higher before vascular leak...

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Bibliographic Details
Main Authors: Cintia Ferreira Marinho, Elzinandes Leal Azeredo, Amanda Torrentes-Carvalho, Alessandro Marins-Dos-Santos, Claire Fernandes Kubelka, Luiz José de Souza, Rivaldo Venâncio Cunha, Luzia Maria de-Oliveira-Pinto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4111305?pdf=render

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http://europepmc.org/articles/PMC4111305?pdf=render

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