Ketamine-Treatment During Late Adolescence Impairs Inhibitory Synaptic Transmission in the Prefrontal Cortex and Working Memory in Adult Rats

Ketamine-Treatment During Late Adolescence Impairs Inhibitory Synaptic Transmission in the Prefrontal Cortex and Working Memory in Adult Rats

Schizophrenia (SZ) is associated with changes in the structure and function of several brain areas. Several findings suggest that these impairments are related to a dysfunction in γ-aminobutyric acid (GABA) neurotransmission in brain areas such as the medial prefrontal cortex (mPFC), the hippocampus...

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Bibliographic Details
Main Authors: Miguel Ángel Pérez, Camila Morales, Odra Santander, Francisca García, Isabel Gómez, Valentín Peñaloza-Sancho, Pablo Fuentealba, Alexies Dagnino-Subiabre, Pablo R. Moya, Marco Fuenzalida
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
ketamine
late adolescence
PV-INs
GABA
mPFC
schizophrenia-like behavior
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00372/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00372/full

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