RNA-Eluting Surfaces for the Modulation of Gene Expression as A Novel Stent Concept

RNA-Eluting Surfaces for the Modulation of Gene Expression as A Novel Stent Concept

Presently, a new era of drug-eluting stents is continuing to improve late adverse effects such as thrombosis after coronary stent implantation in atherosclerotic vessels. The application of gene expression–modulating stents releasing specific small interfering RNAs (siRNAs) or messenger RNAs (mRNAs)...

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Bibliographic Details
Main Authors: Olivia Koenig, Diane Zengerle, Nadja Perle, Susanne Hossfeld, Bernd Neumann, Andreas Behring, Meltem Avci-Adali, Tobias Walker, Christian Schlensak, Hans Peter Wendel, Andrea Nolte
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:Pharmaceuticals
Subjects:
atherosclerosis
drug eluting stents
PLGA films
gene delivery
local transfection
siICAM-1
gene knockdown
mRNA
Online Access:http://www.mdpi.com/1424-8247/10/1/23

Internet

http://www.mdpi.com/1424-8247/10/1/23

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