Intravenous injection of beta-amyloid seeds promotes cerebral amyloid angiopathy (CAA)

Abstract Seeding and spread of beta-amyloid (Aβ) pathologies have been considered to be based on prion-like mechanisms. However, limited transmissibility of Aβ seeding activity upon peripheral exposure would represent a key difference to prions, not only in terms of pathogenesis but also in terms of...

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Bibliographic Details
Main Authors: Michael Burwinkel, Manuel Lutzenberger, Frank L. Heppner, Walter Schulz-Schaeffer, Michael Baier
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Acta Neuropathologica Communications
Online Access:http://link.springer.com/article/10.1186/s40478-018-0511-7