Immunogenicity of a Fap2 peptide mimotope of Fusobacterium nucleatum and its potential use in the diagnosis of colorectal cancer

Immunogenicity of a Fap2 peptide mimotope of Fusobacterium nucleatum and its potential use in the diagnosis of colorectal cancer

Abstract Background The role of Fusobacterium nucleatum Fap2 protein in the development of colorectal cancer has recently been explained. Fap2, when bound to the human inhibitory receptor, TIGIT, inhibits the cytotoxic activity of natural killer (NK) cells against cancer cells, thus, allowing prolif...

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Bibliographic Details
Main Authors: Leonardo A. Guevarra, Andrea Claudine F. Afable, Patricia Joyce O. Belza, Karen Joy S. Dy, Scott Justin Q. Lee, Teresa T. Sy-Ortin, Pia Marie S. P. Albano
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Infectious Agents and Cancer
Subjects:
Fap2 protein
Fusobacterium nucleatum
ELISA
Colorectal cancer
Immunodiagnostics
Online Access:http://link.springer.com/article/10.1186/s13027-018-0184-7

Internet

http://link.springer.com/article/10.1186/s13027-018-0184-7

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