Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1
The glutamine fructose-6-phosphate amidotransferase 1 (GFAT-1) is the rate-limiting enzyme in the hexosamine pathway producing uridine 5’-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc), an essential glycosylation precursor. Here, the authors dissect the mechanisms of GFAT-1 regulation by protein kina...
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| Format: | Article |
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Nature Publishing Group
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22320-y |
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doaj-239d229d7b824a359ee93d56ac13b6882021-04-18T11:13:35ZengNature Publishing GroupNature Communications2041-17232021-04-0112111410.1038/s41467-021-22320-yProtein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1Sabine Ruegenberg0Felix A. M. C. Mayr1Ilian Atanassov2Ulrich Baumann3Martin S. Denzel4Max Planck Institute for Biology of AgeingMax Planck Institute for Biology of AgeingMax Planck Institute for Biology of AgeingInstitute of Biochemistry, University of CologneMax Planck Institute for Biology of AgeingThe glutamine fructose-6-phosphate amidotransferase 1 (GFAT-1) is the rate-limiting enzyme in the hexosamine pathway producing uridine 5’-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc), an essential glycosylation precursor. Here, the authors dissect the mechanisms of GFAT-1 regulation by protein kinase A (PKA)-mediated phosphorylation.https://doi.org/10.1038/s41467-021-22320-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sabine Ruegenberg Felix A. M. C. Mayr Ilian Atanassov Ulrich Baumann Martin S. Denzel |
| spellingShingle |
Sabine Ruegenberg Felix A. M. C. Mayr Ilian Atanassov Ulrich Baumann Martin S. Denzel Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1 Nature Communications |
| author_facet |
Sabine Ruegenberg Felix A. M. C. Mayr Ilian Atanassov Ulrich Baumann Martin S. Denzel |
| author_sort |
Sabine Ruegenberg |
| title |
Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1 |
| title_short |
Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1 |
| title_full |
Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1 |
| title_fullStr |
Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1 |
| title_full_unstemmed |
Protein kinase A controls the hexosamine pathway by tuning the feedback inhibition of GFAT-1 |
| title_sort |
protein kinase a controls the hexosamine pathway by tuning the feedback inhibition of gfat-1 |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-04-01 |
| description |
The glutamine fructose-6-phosphate amidotransferase 1 (GFAT-1) is the rate-limiting enzyme in the hexosamine pathway producing uridine 5’-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc), an essential glycosylation precursor. Here, the authors dissect the mechanisms of GFAT-1 regulation by protein kinase A (PKA)-mediated phosphorylation. |
| url |
https://doi.org/10.1038/s41467-021-22320-y |
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