MUS81 Participates in the Progression of Serous Ovarian Cancer Associated With Dysfunctional DNA Repair System

MUS81 Participates in the Progression of Serous Ovarian Cancer Associated With Dysfunctional DNA Repair System

Objective: Methyl methanesulfonate ultraviolet sensitive gene clone 81 (MUS81) is a structure-specific endonuclease that plays a pivotal role in the DNA repair system of cancer cells. In this study, we aim to elucidate the potential association between the dysfunction of MUS81 and the progression of...

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Bibliographic Details
Main Authors: Renquan Lu, Suhong Xie, Yanchun Wang, Hui Zheng, Hongqin Zhang, Minjie Deng, Weizhong Shi, Ailing Zhong, Miaomiao Chen, Meiqin Zhang, Xiaofeng Xu, Masood A. Shammas, Lin Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Oncology
Subjects:
ovarian cancer
MUS81
DNA damage
homologous recombination (HR)
chemotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01189/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01189/full

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