Formulation of Liver-Specific PLGA-DY-635 Nanoparticles Loaded with the Protein Kinase C Inhibitor Bisindolylmaleimide I

Formulation of Liver-Specific PLGA-DY-635 Nanoparticles Loaded with the Protein Kinase C Inhibitor Bisindolylmaleimide I

Bisindolylmaleimide I (BIM-I) is a competitive pan protein kinase C inhibitor with anti-inflammatory and anti-metastatic properties, suggested to treat inflammatory diseases and various cancer entities. However, despite its therapeutic potential, BIM-I has two major drawbacks, i.e., it has a poor wa...

Full description

Bibliographic Details
Main Authors: Blerina Shkodra, Adrian T. Press, Antje Vollrath, Ivo Nischang, Stephanie Schubert, Stephanie Hoeppener, Dorothee Haas, Christoph Enzensperger, Marc Lehmann, Petra Babic, Kay Jovana Benecke, Anja Traeger, Michael Bauer, Ulrich S. Schubert
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceutics
Subjects:
active targeting
bisindolylmaleimide I
drug delivery
liver disease
nanoparticle formulation
PKC
Online Access:https://www.mdpi.com/1999-4923/12/11/1110

Internet

https://www.mdpi.com/1999-4923/12/11/1110

Similar Items