Homoharringtonine regulates the alternative splicing of Bcl-x and caspase 9 through a protein phosphatase 1-dependent mechanism

Homoharringtonine regulates the alternative splicing of Bcl-x and caspase 9 through a protein phosphatase 1-dependent mechanism

Abstract Background Homoharringtonine (HHT) is a natural alkaloid with potent antitumor activity, but its precise mechanism of action is still poorly understood. Methods We examined the effect of HHT on alternative splicing of Bcl-x and Caspase 9 in various cells using semi-quantitative reverse tran...

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Bibliographic Details
Main Authors: Qi Sun, Shiyue Li, Junjun Li, Qiuxia Fu, Zhongyuan Wang, Bo Li, Shan-Shan Liu, Zijie Su, Jiaxing Song, Desheng Lu
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Complementary and Alternative Medicine
Subjects:
Homoharringtonine, Alternative splicing
Bcl-x
Caspase 9
Protein phosphatase 1
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12906-018-2233-6

Internet

http://link.springer.com/article/10.1186/s12906-018-2233-6

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