Different pattern of immunoglobulin gene usage by HIV-1 compared to non-HIV-1 antibodies derived from the same infected subject.

Different pattern of immunoglobulin gene usage by HIV-1 compared to non-HIV-1 antibodies derived from the same infected subject.

A biased usage of immunoglobulin (Ig) genes is observed in human anti-HIV-1 monoclonal antibodies (mAbs) resulting probably from compensation to reduced usage of the VH3 family genes, while the other alternative suggests that this bias usage is due to antigen requirements. If the antigen structure i...

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Bibliographic Details
Main Authors: Liuzhe Li, Xiao-Hong Wang, Sagarika Banerjee, Barbara Volsky, Constance Williams, Diana Virland, Arthur Nadas, Michael S Seaman, Xuemin Chen, Paul Spearman, Susan Zolla-Pazner, Miroslaw K Gorny
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3382572?pdf=render

Internet

http://europepmc.org/articles/PMC3382572?pdf=render

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