Increased Bone Resorption during Lactation in Pycnodysostosis

Increased Bone Resorption during Lactation in Pycnodysostosis

Pycnodysostosis, a rare autosomal recessive skeletal dysplasia, is caused by a deficiency of cathepsin K. Patients have impaired bone resorption in the presence of normal or increased numbers of multinucleated, but dysfunctional, osteoclasts. Cathepsin K degrades collagen type I and generates N-telo...

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Bibliographic Details
Main Authors: Ineke D.C. Jansen, Socrates E. Papapoulos, Nathalie Bravenboer, Teun J. de Vries, Natasha M. Appelman-Dijkstra
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
pycnodystostosis
bone remodeling
osteoclasts
cathepsin K
lactation
osteocytes
Online Access:https://www.mdpi.com/1422-0067/22/4/1810

Internet

https://www.mdpi.com/1422-0067/22/4/1810

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