Evolving neoantigen profiles in colorectal cancers with DNA repair defects

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

Abstract Background Neoantigens that arise as a consequence of tumor-specific mutations can be recognized by T lymphocytes leading to effective immune surveillance. In colorectal cancer (CRC) and other tumor types, a high number of neoantigens is associated with patient response to immune therapies....

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Bibliographic Details
Main Authors: Giuseppe Rospo, Annalisa Lorenzato, Nabil Amirouchene-Angelozzi, Alessandro Magrì, Carlotta Cancelliere, Giorgio Corti, Carola Negrino, Vito Amodio, Monica Montone, Alice Bartolini, Ludovic Barault, Luca Novara, Claudio Isella, Enzo Medico, Andrea Bertotti, Livio Trusolino, Giovanni Germano, Federica Di Nicolantonio, Alberto Bardelli
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Genome Medicine
Subjects:
Colorectal cancer
Neoantigen
DNA repair
Immune response
Mutational signature
Online Access:http://link.springer.com/article/10.1186/s13073-019-0654-6

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http://link.springer.com/article/10.1186/s13073-019-0654-6

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