Cryptotanshinone Regulates Androgen Synthesis through the ERK/c-Fos/CYP17 Pathway in Porcine Granulosa Cells

The aim of the study is to investigate the molecular mechanism behind androgen reduction in porcine granulosa cells (pGCs) with Salvia miltiorrhiza Bunge extract cryptotanshinone. PGCs were isolated from porcine ovaries and identified. Androgen excess model of the pGCs was induced with the MAPK inhi...

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Bibliographic Details
Main Authors: Danfeng Ye, Meifang Li, Yuehui Zhang, Xinhua Wang, Hua Liu, Wanting Wu, Wanying Ma, Kewei Quan, Ernest H. Y. Ng, Xiaoke Wu, Maohua Lai, Hongxia Ma
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2017/5985703