Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia).

Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia).

ZIP14 (slc39A14) is a zinc transporter induced in response to pro-inflammatory stimuli. ZIP14 induction accompanies the reduction in serum zinc (hypozincemia) of acute inflammation. ZIP14 can transport Zn(2+) and non-transferrin-bound Fe(2+) in vitro. Using a Zip14(-/-) mouse model we demonstrated t...

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Bibliographic Details
Main Authors: Tolunay Beker Aydemir, Shou-Mei Chang, Gregory J Guthrie, Alyssa B Maki, Moon-Suhn Ryu, Afife Karabiyik, Robert J Cousins
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3480510?pdf=render

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http://europepmc.org/articles/PMC3480510?pdf=render

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