A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice

A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice

Abstract Background Cytotoxic chemotherapeutics form the cornerstone of systemic treatment of many cancers. Patients are dosed at maximum tolerated dose (MTD), which is carefully determined in phase I studies. In contrast, in murine studies, dosages are often based on customary practice or small pil...

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Bibliographic Details
Main Authors: Wayne J. Aston, Danika E. Hope, Anna K. Nowak, Bruce W. Robinson, Richard A. Lake, W. Joost Lesterhuis
Format: Article
Language:English
Published: BMC 2017-10-01
Series:BMC Cancer
Subjects:
Chemotherapy
Mice
Dose optimization
Maximum tolerated dose
MTD
Supportive care
Online Access:http://link.springer.com/article/10.1186/s12885-017-3677-7

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http://link.springer.com/article/10.1186/s12885-017-3677-7

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