Estrogen-ERα signaling and DNA hypomethylation co-regulate expression of stem cell protein PIWIL1 in ERα-positive endometrial cancer cells

Estrogen-ERα signaling and DNA hypomethylation co-regulate expression of stem cell protein PIWIL1 in ERα-positive endometrial cancer cells

Abstract Background We previously identified PIWIL1 as an oncogene involved in endometrial carcinogenesis. However, the mechanism of Piwil1 mediated regulation of tumorigenesis remains poorly understood. Methods The expression levels of target genes in endometrial cancer cells were detected by quant...

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Bibliographic Details
Main Authors: Zheng Chen, Hua-Jing Yang, Qin Lin, Min-Jiao Zhu, Ying-Ying Yu, Xiao-Ying He, Xiao-Ping Wan
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Cell Communication and Signaling
Subjects:
Endometrial carcinoma
PIWIL1
ERα
Cell Proliferation
DNA methylation
Online Access:http://link.springer.com/article/10.1186/s12964-020-00563-4

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http://link.springer.com/article/10.1186/s12964-020-00563-4

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