Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice

Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice

Poly(A)-binding protein (PABP) is an RNA binding protein with translation function. Here, Barragán-Iglesias and colleagues devise an RNA mimic that inhibits PABP activity, and show that inhibitors can reduce animal’s pain response in vivo when injected locally.

Bibliographic Details
Main Authors: Paulino Barragán-Iglesias, Tzu-Fang Lou, Vandita D. Bhat, Salim Megat, Michael D. Burton, Theodore J. Price, Zachary T. Campbell
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02449-5

Internet

https://doi.org/10.1038/s41467-017-02449-5

Similar Items