Peroxiredoxin-mediated disulfide bond formation is required for nucleocytoplasmic translocation and secretion of HMGB1 in response to inflammatory stimuli

Peroxiredoxin-mediated disulfide bond formation is required for nucleocytoplasmic translocation and secretion of HMGB1 in response to inflammatory stimuli

The nuclear protein HMGB1 (high mobility group box 1) is secreted by monocytes-macrophages in response to inflammatory stimuli and serves as a danger-associated molecular pattern. Acetylation and phosphorylation of HMGB1 are implicated in the regulation of its nucleocytoplasmic translocation for sec...

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Bibliographic Details
Main Authors: Man Sup Kwak, Hee Sue Kim, Khulan Lkhamsuren, Young Hun Kim, Myeong Gil Han, Jae Min Shin, In Ho Park, Woo Joong Rhee, Se Kyoung Lee, Sue Goo Rhee, Jeon-Soo Shin
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231719302575

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http://www.sciencedirect.com/science/article/pii/S2213231719302575

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