Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus

Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus

Abstract Background In this study, we tested five series of pyrazole-5-carboxamide compounds (n = 55) for activity against parasitic stages of the nematode Haemonchus contortus (barber’s pole worm), one of the most pathogenic parasites of ruminants. Methods In an optimised, whole-organism screening...

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Bibliographic Details
Main Authors: Yaqing Jiao, Sarah Preston, Hongjian Song, Abdul Jabbar, Yuxiu Liu, Jonathan Baell, Andreas Hofmann, Dana Hutchinson, Tao Wang, Anson V. Koehler, Gillian M. Fisher, Katherine T. Andrews, Benoît Laleu, Michael J. Palmer, Jeremy N. Burrows, Timothy N. C. Wells, Qingmin Wang, Robin B. Gasser
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Parasites & Vectors
Subjects:
Haemonchus contortus
Phenotypic screening
Tolfenpyrad
Synthetic pyrazole-5-carboxamide derivatives
Mitochondrial respiratory chain
Online Access:http://link.springer.com/article/10.1186/s13071-017-2191-8

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http://link.springer.com/article/10.1186/s13071-017-2191-8

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