The p53 codon 72 PRO/PRO genotype may be associated with initial central visual field defects in caucasians with primary open angle glaucoma.

The p53 codon 72 PRO/PRO genotype may be associated with initial central visual field defects in caucasians with primary open angle glaucoma.

BACKGROUND:Loss of vision in glaucoma is due to apoptotic retinal ganglion cell loss. While p53 modulates apoptosis, gene association studies between p53 variants and glaucoma have been inconsistent. In this study we evaluate the association between a p53 variant functionally known to influence apop...

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Main Authors: Janey L Wiggs, Alex W Hewitt, Bao Jian Fan, Dan Yi Wang, Dayse R Figueiredo Sena, Colm O'Brien, Anthony Realini, Jamie E Craig, David P Dimasi, David A Mackey, Jonathan L Haines, Louis R Pasquale
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3458938?pdf=render

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http://europepmc.org/articles/PMC3458938?pdf=render

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