Altered goblet cell differentiation and surface mucus properties in Hirschsprung disease.

Altered goblet cell differentiation and surface mucus properties in Hirschsprung disease.

Hirschsprung disease-associated enterocolitis (HAEC) leads to significant mortality and morbidity, but its pathogenesis remains unknown. Changes in the colonic epithelium related to goblet cells and the luminal mucus layer have been postulated to play a key role. Here we show that the colonic epithe...

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Bibliographic Details
Main Authors: Jay R Thiagarajah, Hasan Yildiz, Taylor Carlson, Alyssa R Thomas, Casey Steiger, Alberto Pieretti, Lawrence R Zukerberg, Rebecca L Carrier, Allan M Goldstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4063789?pdf=render

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http://europepmc.org/articles/PMC4063789?pdf=render

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