A role for α-Synuclein in axon growth and its implications in corticostriatal glutamatergic plasticity in Parkinson’s disease

A role for α-Synuclein in axon growth and its implications in corticostriatal glutamatergic plasticity in Parkinson’s disease

Abstract Background α-Synuclein (α-Syn) is a protein implicated in the pathogenesis of Parkinson’s disease (PD). α-Syn has been shown to associate with membranes and bind acidic phospholipids. However, the physiological importance of these associations to the integrity of axons is not fully clear. M...

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Bibliographic Details
Main Authors: Meir Schechter, Jessica Grigoletto, Suaad Abd-Elhadi, Hava Glickstein, Alexander Friedman, Geidy E. Serrano, Thomas G. Beach, Ronit Sharon
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Molecular Neurodegeneration
Subjects:
Parkinson’s disease
Corticostriatal axons
α-Synuclein
Phosphatidylinositol 4,5-bisphosphate (PI4,5P2)
White matter tracts (WMTs)
Axonal injury
Online Access:http://link.springer.com/article/10.1186/s13024-020-00370-y

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http://link.springer.com/article/10.1186/s13024-020-00370-y

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