Antiplasmodial Activity and In Vivo Bio-Distribution of Chloroquine Molecules Released with a 4-(4-Ethynylphenyl)-Triazole Moiety from Organometallo-Cobalamins

Antiplasmodial Activity and In Vivo Bio-Distribution of Chloroquine Molecules Released with a 4-(4-Ethynylphenyl)-Triazole Moiety from Organometallo-Cobalamins

We have explored the possibility of using organometallic derivatives of cobalamin as a scaffold for the delivery of the same antimalarial drug to both erythro- and hepatocytes. This hybrid molecule approach, intended as a possible tool for the development of multi-stage antimalarial agents, pivots o...

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Bibliographic Details
Main Authors: Jeremie Rossier, Sara Nasiri Sovari, Aleksandar Pavic, Sandra Vojnovic, Tameryn Stringer, Sarah Bättig, Gregory S. Smith, Jasmina Nikodinovic-Runic, Fabio Zobi
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
antimalarial
prodrug
chloroquine
triazole
cobalamin
in vivo
zebrafish model
Online Access:https://www.mdpi.com/1420-3049/24/12/2310

Internet

https://www.mdpi.com/1420-3049/24/12/2310

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