Antiplasmodial Activity and In Vivo Bio-Distribution of Chloroquine Molecules Released with a 4-(4-Ethynylphenyl)-Triazole Moiety from Organometallo-Cobalamins
We have explored the possibility of using organometallic derivatives of cobalamin as a scaffold for the delivery of the same antimalarial drug to both erythro- and hepatocytes. This hybrid molecule approach, intended as a possible tool for the development of multi-stage antimalarial agents, pivots o...
Main Authors: | Jeremie Rossier, Sara Nasiri Sovari, Aleksandar Pavic, Sandra Vojnovic, Tameryn Stringer, Sarah Bättig, Gregory S. Smith, Jasmina Nikodinovic-Runic, Fabio Zobi |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-06-01
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Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/24/12/2310 |
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