ROS Promote Ox-LDL-Induced Platelet Activation by Up-Regulating Autophagy Through the Inhibition of the PI3K/AKT/mTOR Pathway

ROS Promote Ox-LDL-Induced Platelet Activation by Up-Regulating Autophagy Through the Inhibition of the PI3K/AKT/mTOR Pathway

Background/Aims: Oxidized low-density lipoprotein (oxLDL) promotes unregulated platelet activation in patients with dyslipidemic disorders. Although oxLDL stimulates activating signaling, researchers have not clearly determined how these events drive accelerated thrombosis. Here, we describe the mec...

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Bibliographic Details
Main Authors: Xiang Wang, Yun-Feng Fu, Xiao Liu, Guo Feng, Dan Xiong, Guang-Fu Mu, Fang-Ping Chen
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Ros
PI3K/AKT/mTOR signaling pathway
Autophagy
Ox-LDL
Platelet activation
Online Access:https://www.karger.com/Article/FullText/494795

Internet

https://www.karger.com/Article/FullText/494795

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