Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients.

Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients.

Xeroderma pigmentosum (XP) is caused by defects in the nucleotide excision repair (NER) pathway. NER removes helix-distorting DNA lesions, such as UV-induced photodimers, from the genome. Patients suffering from XP exhibit exquisite sun sensitivity, high incidence of skin cancer, and in some cases n...

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Bibliographic Details
Main Authors: Anwaar Ahmad, Jacqueline H Enzlin, Nikhil R Bhagwat, Nils Wijgers, Anja Raams, Esther Appledoorn, Arjan F Theil, Jan H J Hoeijmakers, Wim Vermeulen, Nicolaas G J Jaspers, Orlando D Schärer, Laura J Niedernhofer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2832669?pdf=render

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http://europepmc.org/articles/PMC2832669?pdf=render

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