LGR5 promotes epithelial ovarian cancer proliferation, metastasis, and epithelial–mesenchymal transition through the Notch1 signaling pathway

LGR5 promotes epithelial ovarian cancer proliferation, metastasis, and epithelial–mesenchymal transition through the Notch1 signaling pathway

Abstract Leucine‐rich repeat‐containing G protein‐coupled receptor 5 (LGR5) plays a vital role in the development of malignant tumors; however, its biological role and underlying mechanism in epithelial ovarian cancer (EOC) remain unclear. In this study, we aimed to investigate the biological functi...

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Bibliographic Details
Main Authors: Wenxue Liu, Jing Zhang, Xupei Gan, Fangqian Shen, Xiaoming Yang, Na Du, Dandan Xia, Lei Liu, Lianqiao Qiao, Jufang Pan, Yunyan Sun, Xiaowei Xi
Format: Article
Language:English
Published: Wiley 2018-07-01
Series:Cancer Medicine
Subjects:
Epithelial–mesenchymal transition
epithelial ovarian cancer
LGR5
metastasis
Notch1 signaling pathway
Online Access:https://doi.org/10.1002/cam4.1485

Internet

https://doi.org/10.1002/cam4.1485

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