Interleukin-7 receptor blockade suppresses adaptive and innate inflammatory responses in experimental colitis

Interleukin-7 receptor blockade suppresses adaptive and innate inflammatory responses in experimental colitis

<p>Abstract</p> <p>Background</p> <p>Interleukin-7 (IL-7) acts primarily on T cells to promote their differentiation, survival, and homeostasis. Under disease conditions, IL-7 mediates inflammation through several mechanisms and cell types. In humans, IL-7 and its recep...

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Bibliographic Details
Main Authors: Willis Cynthia R, Seamons Audrey, Maxwell Joe, Treuting Piper M, Nelson Laurel, Chen Guang, Phelps Susan, Smith Carole L, Brabb Thea, Iritani Brian M, Maggio-Price Lillian
Format: Article
Language:English
Published: BMC 2012-10-01
Series:Journal of Inflammation
Subjects:
IL-7R
Colitis
<it>Mdr1a</it><sup>−/−</sup> mice
<it>Rag2</it><sup>−/−</sup> mice
<it>Helicobacter bilis</it>
Online Access:http://www.journal-inflammation.com/content/9/1/39

Internet

http://www.journal-inflammation.com/content/9/1/39

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