Lynch Syndrome: An Updated Review

Lynch syndrome is one of the most common cancer susceptibility syndromes. Individuals with Lynch syndrome have a 50%–70% lifetime risk of colorectal cancer, 40%–60% risk of endometrial cancer, and increased risks of several other malignancies. It is caused by germline mutations in the DNA mismatch...

Full description

Bibliographic Details
Main Authors: Rishabh Sehgal, Kieran Sheahan, Patrick R. O'Connell, Ann M. Hanly, Sean T. Martin, Desmond C. Winter
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:Genes
Subjects:
Online Access:http://www.mdpi.com/2073-4425/5/3/497