Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues

Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues

Mice harbouring a dentin matrix protein 1 (Dmp1) promoter-driven human diphtheria toxin (DT) receptor (HDTR) transgene (Tg) have recently been used to attain targeted ablation of osteocytes by diphtheria toxin (DT) treatment in order to define osteocyte function. Use of these Tg mice has asserted me...

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Bibliographic Details
Main Authors: Ahmed Al-Jazzar, Behzad Javaheri, Matt Prideaux, Alan Boyde, Cheryl L. Scudamore, Chahrazad Cherifi, Eric Hay, Mark Hopkinson, Michael Boyd, Martine Cohen-Solal, Colin Farquharson, Andrew A. Pitsillides
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:International Journal of Molecular Sciences
Subjects:
osteocyte
diphtheria toxin receptor
bone
Online Access:http://www.mdpi.com/1422-0067/18/1/29

Internet

http://www.mdpi.com/1422-0067/18/1/29

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