Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition

Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition

<p>Abstract</p> <p>Background</p> <p>Clear cell renal cell carcinoma (ccRCC) accounts for more than 80% of the cases of renal cell carcinoma. In ccRCC deactivation of Von-Hippel-Lindau (VHL) gene contributes to the constitutive expression of hypoxia inducible factors 1...

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Bibliographic Details
Main Authors: Chintala Sreenivasulu, Najrana Tanbir, Toth Karoly, Cao Shousong, Durrani Farukh A, Pili Roberto, Rustum Youcef M
Format: Article
Language:English
Published: BMC 2012-07-01
Series:BMC Cancer
Subjects:
Prolyl hydroxylases
Hypoxia-inducible factor
Clear cell renal cell carcinoma
Selenium
Online Access:http://www.biomedcentral.com/1471-2407/12/293

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http://www.biomedcentral.com/1471-2407/12/293

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