Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations
<p>Abstract</p> <p>Background</p> <p>Mutations in the presenilin (<it>PSEN</it>) genes are associated with early-onset familial Alzheimer's disease (FAD). Biochemical characterizations and comparisons have revealed that many PSEN mutations alter γ-secre...
Main Authors: | , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2008-11-01
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Series: | Molecular Neurodegeneration |
Online Access: | http://www.molecularneurodegeneration.com/content/3/1/20 |