How does thymus infection by coxsackievirus contribute to the pathogenesis of type 1 diabetes?

How does thymus infection by coxsackievirus contribute to the pathogenesis of type 1 diabetes?

Through synthesis and presentation of neuroendocrine self-antigens by major histocompatibility complex (MHC) proteins, thymic epithelial cells (TECs) play a crucial role in programming central immune self-tolerance to neuroendocrine functions. Insulin-like growth factor-2 (IGF-2) is the dominant gen...

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Bibliographic Details
Main Authors: Hélène eMichaux, Henri Joseph Martens, Hela eJaidane, Aymen eHalouani, Didier eHober, Vincent eGEENEN
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Immunology
Subjects:
Coxsackievirus Infections
Enterovirus
Insulin
Insulin-Like Growth Factor II
Thymus Gland
type 1 diabetes
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00338/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00338/full

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