Exome Sequencing of Cell-Free DNA from Metastatic Cancer Patients Identifies Clinically Actionable Mutations Distinct from Primary Disease.

Exome Sequencing of Cell-Free DNA from Metastatic Cancer Patients Identifies Clinically Actionable Mutations Distinct from Primary Disease.

The identification of the molecular drivers of cancer by sequencing is the backbone of precision medicine and the basis of personalized therapy; however, biopsies of primary tumors provide only a snapshot of the evolution of the disease and may miss potential therapeutic targets, especially in the m...

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Bibliographic Details
Main Authors: Timothy M Butler, Katherine Johnson-Camacho, Myron Peto, Nicholas J Wang, Tara A Macey, James E Korkola, Theresa M Koppie, Christopher L Corless, Joe W Gray, Paul T Spellman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4552879?pdf=render

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http://europepmc.org/articles/PMC4552879?pdf=render

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