Activation of autophagy inhibits nucleotide‐binding oligomerization domain‐like receptor protein 3 inflammasome activation and attenuates myocardial ischemia‐reperfusion injury in diabetic rats

Activation of autophagy inhibits nucleotide‐binding oligomerization domain‐like receptor protein 3 inflammasome activation and attenuates myocardial ischemia‐reperfusion injury in diabetic rats

Abstract Aims/Introduction Diabetic hearts are more vulnerable to ischemia‐reperfusion injury (I/RI). The activation of nucleotide‐binding oligomerization domain‐like receptor protein 3 (NLRP3) inflammasome can mediate the inflammatory process, and hence might contribute to myocardial I/RI. Activati...

Full description

Bibliographic Details
Main Authors: Dengwen Zhang, Yi He, Xiaodong Ye, Yin Cai, Jindong Xu, Liangqing Zhang, Mingyi Li, Hao Liu, Sheng Wang, Zhengyuan Xia
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Journal of Diabetes Investigation
Subjects:
Diabetic myocardium
Myocardial ischemia‐reperfusion injury
Nucleotide‐binding oligomerization domain‐like receptor protein 3 inflammasome
Online Access:https://doi.org/10.1111/jdi.13235

Internet

https://doi.org/10.1111/jdi.13235

Similar Items