Knockdown of Dehydrodolichyl Diphosphate Synthase in the Drosophila Retina Leads to a Unique Pattern of Retinal Degeneration

Knockdown of Dehydrodolichyl Diphosphate Synthase in the Drosophila Retina Leads to a Unique Pattern of Retinal Degeneration

Dehydrodolichyl diphosphate synthase (DHDDS) is a ubiquitously expressed enzyme that catalyzes cis-prenyl chain elongation to produce the poly-prenyl backbone of dolichol. It appears in all tissues including the nervous system and it is a highly conserved enzyme that can be found in all animal speci...

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Bibliographic Details
Main Authors: Tal Brandwine, Reut Ifrah, Tzofia Bialistoky, Rachel Zaguri, Elisheva Rhodes-Mordov, Liliana Mizrahi-Meissonnier, Dror Sharon, Vladimir L. Katanaev, Offer Gerlitz, Baruch Minke
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
DHDDS
photoreceptor degeneration
RNAi
Drosophila
N-glycosylation
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.693967/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.693967/full

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