R269C variant of ESR1: high prevalence and differential function in a subset of pancreatic cancers

R269C variant of ESR1: high prevalence and differential function in a subset of pancreatic cancers

Abstract Background Estrogen receptor α (ESR1) plays a critical role in promoting growth of various cancers. Yet, its role in the development of pancreatic cancer is not well-defined. A less studied region of ESR1 is the hinge region, connecting the ligand binding and DNA domains. rs142712646 is a r...

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Bibliographic Details
Main Authors: Tomer Boldes, Keren Merenbakh-Lamin, Shani Journo, Eliya Shachar, Doron Lipson, Adva Yeheskel, Metsada Pasmanik-Chor, Tami Rubinek, Ido Wolf
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Cancer
Subjects:
Pancreatic cancer
Estrogen receptor
Activation Function-1
SNP
Online Access:http://link.springer.com/article/10.1186/s12885-020-07005-x

Internet

http://link.springer.com/article/10.1186/s12885-020-07005-x

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