Heme Oxygenase-1 Inhibition Sensitizes Human Prostate Cancer Cells towards Glucose Deprivation and Metformin-Mediated Cell Death

Heme Oxygenase-1 Inhibition Sensitizes Human Prostate Cancer Cells towards Glucose Deprivation and Metformin-Mediated Cell Death

High levels of heme oxygenase (HO)-1 have been frequently reported in different human cancers, playing a major role in drug resistance and regulation of cancer cell redox homeostasis. Metformin (MET), a drug widely used for type 2 diabetes, has recently gained interest for treating several cancers....

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Bibliographic Details
Main Authors: Marco Raffaele, Valeria Pittalà, Veronica Zingales, Ignazio Barbagallo, Loredana Salerno, Giovanni Li Volti, Giuseppe Romeo, Giuseppe Carota, Valeria Sorrenti, Luca Vanella
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
prostate cancer
heme oxygenase
metformin
apoptosis
ER stress
HO-1 activity inhibitor
Online Access:https://www.mdpi.com/1422-0067/20/10/2593

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https://www.mdpi.com/1422-0067/20/10/2593

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