Pro-fibrotic phenotype of bone marrow stromal cells in Modic type 1 changes

Pro-fibrotic phenotype of bone marrow stromal cells in Modic type 1 changes

Modic type 1 changes (MC1) are painful vertebral bone marrow lesions frequently found in patients suffering from chronic low-back pain. Marrow fibrosis is a hallmark of MC1. Bone marrow stromal cells (BMSCs) are key players in other fibrotic bone marrow pathologies, yet their role in MC1 is unknown....

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Bibliographic Details
Main Authors: I Heggli, S Epprecht, A Juengel, R Schuepbach, N Farshad-Amacker, C German, T Mengis, N Herger, L Straumann, S Baumgartner, M Betz, JM Spirig, F Wanivenhaus, N Ulrich, D Bellut, F Brunner, M Farshad, O Distler, S Dudli
Format: Article
Language:English
Published: AO Research Institute Davos 2021-06-01
Series:European Cells & Materials
Subjects:
modic change
fibrosis
bone marrow stromal cells
mesenchymal stem cell
extracellular matrix
cell differentiation
cell contractility
cell adhesion
focal adhesion kinase
pro-fibrotic phenotype
Online Access:https://www.ecmjournal.org/papers/vol041/pdf/v041a42.pdf

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https://www.ecmjournal.org/papers/vol041/pdf/v041a42.pdf

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