Strategies for B-cell receptor repertoire analysis in Primary Immunodeficiencies:From severe combined immunodeficiency to common variable immunodeficiency

Strategies for B-cell receptor repertoire analysis in Primary Immunodeficiencies:From severe combined immunodeficiency to common variable immunodeficiency

The antigen receptor repertoires of B and T cells form the basis of the adaptive immune response. The repertoires should be sufficiently diverse to recognize all possible pathogens. However, careful selection is needed to prevent responses to self or harmless antigens. Limited antigen receptor reper...

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Bibliographic Details
Main Authors: Hanna eIJspeert, Marjolein eWentink, David evan Zessen, Gertjan J Driessen, Virgil A.S.H. Dalm, Martin P van Hagen, Ingrid ePico-Knijnenburg, Erik J Simons, Jacques J.M. van Dongen, Andrew P. Stubbs, Mirjam eVan Der Burg
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Immunology
Subjects:
V(D)J Recombination
immunodeficiency
next generation sequencing
CVID
repertoire
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00157/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00157/full

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