PS1/γ-Secretase-Mediated Cadherin Cleavage Induces β-Catenin Nuclear Translocation and Osteogenic Differentiation of Human Bone Marrow Stromal Cells

PS1/γ-Secretase-Mediated Cadherin Cleavage Induces β-Catenin Nuclear Translocation and Osteogenic Differentiation of Human Bone Marrow Stromal Cells

Bone marrow stromal cells (BMSCs) are considered a promising tool for bone bioengineering. However, the mechanisms controlling osteoblastic commitment are still unclear. Osteogenic differentiation of BMSCs requires the activation of β-catenin signaling, classically known to be regulated by the canon...

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Bibliographic Details
Main Authors: Danielle C. Bonfim, Rhayra B. Dias, Anneliese Fortuna-Costa, Leonardo Chicaybam, Daiana V. Lopes, Hélio S. Dutra, Radovan Borojevic, Martin Bonamino, Claudia Mermelstein, Maria Isabel D. Rossi
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Stem Cells International
Online Access:http://dx.doi.org/10.1155/2016/3865315

Internet

http://dx.doi.org/10.1155/2016/3865315

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