SimuSCoP: reliably simulate Illumina sequencing data based on position and context dependent profiles

SimuSCoP: reliably simulate Illumina sequencing data based on position and context dependent profiles

Abstract Background A number of simulators have been developed for emulating next-generation sequencing data by incorporating known errors such as base substitutions and indels. However, their practicality may be degraded by functional and runtime limitations. Particularly, the positional and genomi...

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Bibliographic Details
Main Authors: Zhenhua Yu, Fang Du, Rongjun Ban, Yuanwei Zhang
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Bioinformatics
Subjects:
Next-generation sequencing
Simulators
Base substitution errors
Phred base quality
Intra-tumor heterogeneity
Online Access:http://link.springer.com/article/10.1186/s12859-020-03665-5

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http://link.springer.com/article/10.1186/s12859-020-03665-5

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