VHL suppresses RAPTOR and inhibits mTORC1 signaling in clear cell renal cell carcinoma

VHL suppresses RAPTOR and inhibits mTORC1 signaling in clear cell renal cell carcinoma

Abstract Inactivation of the tumor suppressor von Hippel–Lindau (VHL) gene is a key event in hereditary and sporadic clear cell renal cell carcinomas (ccRCC). The mechanistic target of rapamycin (mTOR) signaling pathway is a fundamental regulator of cell growth and proliferation, and hyperactivation...

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Bibliographic Details
Main Authors: Athina Ganner, Christina Gehrke, Marinella Klein, Lena Thegtmeier, Tanja Matulenski, Laura Wingendorf, Lu Wang, Felicitas Pilz, Lars Greidl, Lisa Meid, Fruzsina Kotsis, Gerd Walz, Ian J. Frew, Elke Neumann-Haefelin
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-94132-5

Internet

https://doi.org/10.1038/s41598-021-94132-5

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