A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer

A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer

Alcohol and smoking are both associated with oral/oropharyngeal cancer risk, but independent effects are unclear given their relatedness. Here, the authors use multivariable Mendelian randomization to show that both alcohol and smoking are independently causal for oral/oropharyngeal cancer.

Bibliographic Details
Main Authors: Mark Gormley, Tom Dudding, Eleanor Sanderson, Richard M. Martin, Steven Thomas, Jessica Tyrrell, Andrew R. Ness, Paul Brennan, Marcus Munafò, Miranda Pring, Stefania Boccia, Andrew F. Olshan, Brenda Diergaarde, Rayjean J. Hung, Geoffrey Liu, George Davey Smith, Rebecca C. Richmond
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19822-6

Internet

https://doi.org/10.1038/s41467-020-19822-6

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